I bought this 4 years ago. I have traveled 3 times to India wearing this backpack. I wear it every waking moment while I'm there. (obvious reasons) As you can imagine it is HOT so wearing a BLACK backpack adds to the sticky, stinky, conditions. Having said that I never found this backpack to be uncomfortable or awkward to pack around. It has gone through a billion airports, stuffed in over head bins, buses, taxi's etc.. and you wouldn't know it by looking at it. Come to think of it- I have never wiped it down and I don't see the need to. It looks fantastic! Not a single tare. Every zipper and strap still works.
I love having everything organized and easily accessible. The bright orange interior is still in great condition.
If you plan on wearing this backpack for long periods of time it is comfortable.
The only discomfort might come from the amount of gear you have packed inside.